two-stage linear step-up procedure of benjamini, krieger and yekutieli  (GraphPad Software Inc)

Journal: Frontiers in Neuroscience

Article Title: 40 Hz Light Flicker Alters Human Brain Electroencephalography Microstates and Complexity Implicated in Brain Diseases

doi: 10.3389/fnins.2021.777183

Figure Lengend Snippet: EEG sequence and PSD analysis. Panel (A) depicts the experimental schema of light flicker stimulation and EEG sequence. Panel (B) is a graphical representation of the intensities of EEG signals in the anatomical brain regions, illustrating the topographic maps of PSD change (Left: rest state; Middle: random flicker; right: 40 Hz light stimulation). Selected positions of O, PO, and P were indicated on the rest state map. The scale bar represents an arbitrary unit (A.U.). EEG recordings were analyzed, and the percentage of the power spectrum between 40 Hz and the total power was calculated from different brain regions as indicated in panels (C) . Statistical comparisons between the three conditions (rest state, random flicker, and the 40 Hz light stimulation) were performed using one-way ANOVA with multiple comparisons using FDR correction using the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli (GraphPad Prism v8). Significant groups were shown in panel (C) . #, ##, ###, and #### indicate the FDR adjusted P < 0.05, P < 0.01, P < 0.001, and P < 0.0001, respectively.

Article Snippet: For multiple comparisons in the analysis of percent power, microstate coverage, duration, occurrence and LZC, we performed FDR correction using the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli (GraphPad Prism V8) for all P values to reduce the risk of type I error.

Techniques: Sequencing

Journal: Frontiers in Neuroscience

Article Title: 40 Hz Light Flicker Alters Human Brain Electroencephalography Microstates and Complexity Implicated in Brain Diseases

doi: 10.3389/fnins.2021.777183

Figure Lengend Snippet: Identification of microstate classes, coverage, duration, occurrence. Panel (A) The global maps were calculated based the aggregated dataset from all participants and were back-fitted to each of the EEG recordings. The labels (A–D) indicate the four microstate classes. The four microstate classes coverage (B) , duration (C) , and occurrence (D) were calculated and shown. Statistical comparisons between the three conditions (rest state, random flicker, and the 40 Hz light stimulation) were performed using one-way ANOVA with multiple comparisons using FDR correction using the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli using GraphPad. Significant groups were shown in panel (B–D) . #, ##, and ### indicate the FDR adjusted P < 0.05, P < 0.01, and P < 0.001, respectively. Error bars are S.E.M.

Article Snippet: For multiple comparisons in the analysis of percent power, microstate coverage, duration, occurrence and LZC, we performed FDR correction using the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli (GraphPad Prism V8) for all P values to reduce the risk of type I error.

Techniques: